Vladimir Bondarenko, PhD
Dr. Bondarenko graduated from Lomonosov Moscow State University with a Master's Degree in Biochemistry in 1986 and earned a Ph.D. from the Shemyakin Institute of Bioorganic Chemistry in 1992. His graduate research focused on regulation of one of the key enzymes of visual signal transduction, cGMP phosphodiesterase 6.
He completed two postdoctoral fellowships at Wayne State University and joined the faculty of the Pharmacology Department at UMDNJ in 2003 where he studied the molecular mechanisms of transcription in prokaryotes and eukaryotes. In 2007, Dr. Bondarenko joined the faculty of Basic Sciences Department of Touro University Nevada to teach medical biochemistry in the Doctor of Osteopathic Medicine and Physician Assistant Studies programs.
Dr. Bondarenko has also taught students in the Master of Science in Medical Health Sciences (MHS) program since it was established in 2009.
- Master of Science in Biochemistry, Lomonosov Moscow State University, Moscow, Russia, 1986
- PhD in Biochemistry, Shemyakin Institute of Bioorganic Chemistry, Moscow, Russia, 1992
- 2009-present: Research Tools (BMS 620), and Scientific Communication (BMS 605), Medical Biochemistry (BMS 680), Touro University Nevada, College of Osteopathic Medicine, NV
- 2007-present: Medical Biochemistry (BSCI 609), Human Science (PA 657), Touro University Nevada, College of Osteopathic Medicine, NV
- 2006: Adjunct Chemistry Professor, General Chemistry, Brookdale Community College, NJ
- 2006: Adjunct Biology Professor, Microbiology with Laboratory, Middlesex County, NJ College, NJ
- 2005-2006: Adjunct Biology Professor, Introduction to Pharmacy, Middlesex County, NJ College, NJ
- 2004-2005: Mentor, Summer Undergraduate Research Program, UMDNJ, NJ
- 2003-2005: Mentor, Graduate Students UMDNJ Graduate School of Biomedical Sciences, NJ
- Dr. Bondarenko is interested in finding a correlation between formation of tau aggregates in the brain of the individuals with dementia and their retinas. His preliminary data demonstrate a positive correlation between increased tau aggregates present in visual cortex of individuals with dementia and amounts of tau in retinal neuronal cells. By establishing a correlation between tau accumulation in retina and neurodegenerative disease it could be possible to do an early diagnosis of tau-related dementia by examination of retina for tau aggregates.
- Dr. Bondarenko is also interested in genetic and epigenetic regulation of the cellular processes in response to such pathological conditions as hypoxia and cancer. By using the mouse as model organism he showed that transcriptional responses to induced acute hypoxia are different for different mice strains. A strain that is less susceptible to develop certain types of cancer had less variations in gene expression in response to hypoxia while a strain that is more susceptible to develop cancer has one order of magnitude more variations in gene expression in response to hypoxia.
- Another project Dr. Bondarenko is actively engaged in is a search for antimicrobial compounds in lichens. A lichen of interest is Parmelia vagans that has been used in folk medicine for centuries to treat a variety of maladies including open wounds and inflammation. His lab has found that the extracts from Parmelia vagans has bactericidal properties. He is working on identification and characterization of bactericidal compounds found in lichen extract.
- Touro University Nevada Intramural Grant 2008 2009 TUN ($8,000) Development an in vitro model system to study transcirptional mechanisms of cardiac myocytes remodeling. Role: PI
- Touro University Nevada Intramural Grant 2010 2011 TUN ($8,000) Interaction between rhodopsin and retinal guanylate cyclase, its role in phototransduction Role: PI
- Touro University Nevada Intramural Grant 2012 2013 TUN ($8,000) Interaction between rhodopsin and retinal guanylate cyclase Role: PI
- Touro University Nevada Intramural Grant 2013 2014 TUN ($8,000) Interaction between rhodopsin and retinal guanylate cyclase in mice retina Role: PI
- Akio Yamazaki, Yuji Nishizawa, Isao Matsuura, Fumio Hayashi, Jiro Usukura and Vladimir Bondarenko, (2013) Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: comparison with brain tau. BBA Molecular Bases of Disease 1832(10): 1549-59.
- Yamazaki A, Hayashi F, Matsuura I, Bondarenko VA. (2011) Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation. FEBS J.,278(11):1854-72.
- Daria A. Gaykalova, Nagarajavel Vivekananthan, Vladimir A. Bondarenko, Blaine Bartholomew, David J. Clark and Vasily M. Studitsky, (2011) A Polar Barrier to Transcription is Circumvented by Remodeler-induced Nucleosome Translocation. Nucleic Acids Res., 39(9):3520-8.
- Bondarenko VA, Hayashi, F., Usukura, J., & Yamazaki, A. (2010) Involvement of rhodopsin and ATP in the activation of membranous guanylate cyclase in retinal photoreceptor outer segment (ROS-GC) by GC-activating proteins (GCAPs): A new link to retinal diseases. Mol.Cell.Biochem. 334(1-2):125-39.
- Yamazaki A, Bondarenko VA, Matsuura I, Tatsumi M, Kurono S, Komori N, Matsumoto H, Hayashi F, Yamazaki RK, Usukura J. (2010) Activation of Mammalian Retinal cGMP Phosphodiesterase (PDE) I. Dissociation of an Inhibitory Subunit from Catalytic Subunits. Mol.Cell.Biochem. 339(1-2):215-33.
- Yamazaki A, Tatsumi M, Bondarenko VA, Kurono S, Komori N, Matsumoto H, Matsuura I, Hayashi F, Yamazaki RK, Usukura J.. (2010) Activation of Mammalian Retinal cGMP Phosphodiesterase (PDE) II. Isolation of Transducin-Activated Bovine PDE. Mol.Cell.Biochem 339(1-2):235-51.
- Gaykalova DA, Kulaeva OI, Bondarenko VA, Studitsky VM. (2009) Preparation and analysis of uniquely positioned mononucleosomes. Methods Mol. Biol., 523:109-23.
- Vladimir A. Bondarenko, Louise M. Steele , Andrea ??jv?_ri, Daria A. Gaykalova, Olga I. Kulaeva, Yury S. Polikanov, Donal S. Luse and Vasily M. Studitsky. (2006) Nucleosomes can form a polar barrier to transcript elongation by RNA polymerase II. Mol Cell. 24(3):469-79.
- M. Rubtsov, Y. S. Polikanov, V.A. Bondarenko, Y.H. Wang, V. M. Studitsky (2006). Chromatin structure can strongly facilitate enhancer action over a distance. PNAS.103(47):17690-5.
- Angelov D, Bondarenko VA, Almagro S, Menoni H, Mongelard F, Hans F, Mietton F, Studitsky VM, Hamiche A, Dimitrov S, Bouvet P. (2006) Nucleolin is a histone chaperone with FACT-like activity and assists remodeling of nucleosomes. EMBO J., 25(8):1669-79
- Cecile-Marie Doyen, Woojin An, Dimitar Angelov, Vladimir A. Bondarenko, Flore Mietton, Vasily Studitsky, Ali Hamiche, Robert G. Roeder, Philippe Bouvet, and Stefan Dimitrov. (2005) Mechanism of Polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol. 26(3): 1156-64.
- Angelov D, Verdel A, An W, Bondarenko VA, Hans F, Doyen CM, Studitsky VM, Hamiche A, Roeder RG, Bouvet P, Dimitrov S (2004) SWI/SNF remodeling and p300 dependent transcription of histone variant H2ABbd nucleosomal arrays. EMBO J, 23(19): 3815-24.
- Rimma Belotserkovskaya, Sangtaek Oh, Vladimir A. Bondarenko, George Orphanides, Vasily M. Studitsky, and Danny Reinberg. (2003) Transcription through Nucleosomes: Understanding a Complex FACT. Science, 301(5636): 1090-3.
- Vladimir A. Bondarenko, Yong Jiang, Ye Liu, Vasily Studitsky. (2003) Communication Over a Large Distance: Enhancers and Insulators. Biochem. Cell. Biol., 81(3): 241-51. Vladimir A. Bondarenko, Yong Jiang, Ye Liu, Vasily M. Studitsky. (2003) Rationally Designed Insulator-Like Element Can Block Enhancer Action In Vitro. EMBO J, 12(18): 4728-37.
- Vladimir A. Bondarenko, Ye Liu, Alexander Ninfa, Vasily M. Studitsky (2003). Assay of prokaryotic enhancer activity over a distance in vitro. Meth. Enzymol., 370: 324-37.
- Association for Research in Vision and Ophthalmology (ARVO)
- American Association for the Advancement of Science (AAAS)
- International Association of Medical Science Educators (IAMSE)
- The American Society for Biochemistry and Molecular Biology (ASBMB)
- The Association of Biochemistry Course Directors (ABCD)
- 2010-present: Associate Professor of Biochemistry, Touro University Nevada, College of Osteopathic Medicine, Henderson, NV
- 2007-2010: Assistant Professor of Biochemistry, Touro University Nevada, College of Osteopathic Medicine, Henderson, NV
- 2006: Adjunct Chemistry Professor, Brookdale Community College, Lincroff, NJ
- 2005-2006: Adjunct Biology Professor, Middlesex County College, Middlesex, NJ
- 2003-2006: Assistant Professor, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Dept. Pharmacology, Piscataway, NJ
- 1999-2003: Senior Research Scientist, Wayne State University, School of Medicine, Dept. Biochemistry and Molecular Biology, Detroit, MI
- 1994-1999: Research Associate, Wayne State University, Kresge Eye Institute, Detroit, MI
- 1992-1994: Research Scientist, Institute of Bioorganic Chemistry, Pushchino, Moscow region, Russia