Brad Haubrich, PhD
Dr. Haubrich joined the Basic Sciences faculty at Touro University Nevada in 2020. He earned his BS in Natural Science from Muhlenberg College and his PhD in Chemistry from Texas Tech University. His graduate research included lipidomics of eukaryotic microbes and targeting sterol biosynthesis in infectious disease. He completed two postdoctoral fellowships, at the Institute for Rare and Neglected Diseases Drug Discovery (iRND3) in Mountain View CA and at Bryant University in Smithfield RI, where his research focused on assay development and identifying new therapeutics against eukaryotic and prokaryotic pathogens.
Prior to coming to TUN, Dr. Haubrich taught undergraduate courses in chemistry and biology at the University of Nevada, Reno and Bryant University. His research interests lie at the intersection of chemistry and biology, including developing assays for drug discovery, repurposing drugs, and identifying new potential targets for treatments of infectious disease.
Ph.D. in Chemistry, Texas Tech University, 2014
B.S. in Natural Science, Muhlenberg College, 2003
Biochemistry
Haubrich BA, Ramesha C, Swinney DC. Assay development and screening using a bioluminescent enzyme assay for NAD biosynthesis by nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1). SLAS Discov. 2020. 25, 33-42.
Roohani K, Haubrich BA, Yue K-L, D’Souza N, Montalbano A, Rynearson T, Menden-Deuer S, Reid CW. Trophic upgrading and mobilization of wax esters in microzooplankton. PeerJ. 2019. 7, e7549.
Haubrich BA. Microbial sterolomics as a chemical biology tool. Molecules. 2018. 23(11), 2768.
Haubrich BA, Swinney DC. Enzyme activity assays for protein kinases: Strategies to identify active substrates. Curr. Drug Discov. Tech. 2016.
Swinney DC, Haubrich BA, Van Liefde I, Vauquelin G. The role of binding kinetics in GPCR drug discovery. Curr. Top. Med. Chem. 2015. 15, 2504-2522.
Leaver DJ, Patkar P, Singha UK, Miller MB, Haubrich BA, Chaudhuri M, Nes WD. Fluorinated sterols are suicide inhibitors of ergosterol biosynthesis and growth in Trypanosoma brucei. Chem. & Biol. 2015. 22, 1374-1383.
Haubrich BA, Singha UK, Miller MB, Nes CR, Anyatonwu H, Lecordier L, Patkar P, Leaver DJ, Villalta F, Vanhollebeke B, Chaudhuri M, Nes WD. Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. J. Lipid Res. 2015. 56, 331-341.
Haubrich BA, Collins EK, Howard AL, Wang Q, Snell WJ, Miller MB, Thomas CD, Pleasant SK, Nes WD. Characterization, mutagenesis and mechanistic analysis of an ancient algal C24-methyltransferase: Implications for sterol biosynthesis in the green lineage. Phytochemistry. 2015. 113, 64-72.
Patkar P, Haubrich BA, Qi M, Nguyen TTM, Thomas CD, Nes WD. C24-Methylation of 26-fluorocycloartenols by recombinant sterol C24-methyltransferase from soybean: Evidence for channel switching and its phylogenetic implications. Biochem. J. 2013. 456, 253-262.
International Chemical Biology Society
American Chemical Society
International Association of Medical Science Educators
Association of Biochemistry Educators
