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Basic Science Faculty Research

View the most recent research of our faculty in the Department of Basic Sciences.

Research interests: Alzheimer’s disease, hypoxia, medicinal plants, cancer, visual signal transduction

1) Stephanie Boue, Brett Fields, Julia Hoeng, Jennifer S Park, Manuel C Peitsch, Walter K Schlage, Marja Talikka, Ilona Binenbaum, Vladimir Bondarenko, et al. (2015)  Enhancement of COPD biological networks using a web-based collaboration interface F1000Research4:32 (doi: 10.12688/f1000research.5984.1)

2) Akio Yamazaki, Yuji Nishizawa, Isao Matsuura, Fumio Hayashi, Jiro Usukura and Vladimir Bondarenko (2013)  Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: comparison with brain tau. BBA Molecular Bases of Disease1832(10): 1549–59.

3) Daria A. Gaykalova, Nagarajavel Vivekananthan, Vladimir A. Bondarenko, Blaine Bartholomew, David J. Clark and Vasily M. Studitsky, (2011) A Polar Barrier to Transcription is Circumvented by Remodeler-induced Nucleosome Translocation. Nucleic Acids Res., 39(9):3520-8.

 

Research interests: Anatomy, morphology, locomotion, evolutionary biology, ontogeny

1) Congdon, KA, Jason Jergenson and Kevin O’Mary (2019, in review) “Factors affecting the placement of the tibial tunnel in ACL repair: A multivariate analysis”. Current Orthopaedic Practices.

2) Congdon, KA and MJ Ravosa (2016) “Get a grip: Substrate orientation and digital grasping pressures in strepsirrhines.” Folia Primatologica87: 224-243.

3) Congdon, KA, AS Hammond and MJ Ravosa (2012). “Differential limb loading in miniature pigs (Sus scrofa domesticus): A test of chondral modeling theory.” Journal of Experimental Biology215: 1472-1483.

Research interests: Female fertility, Ovulation, Extracellular matrix, Hyaluronan, Tumor necrosis factor-induced protein 6

1) Fülöp, C., Szántó,S., Mukhopadhyay, D., Bárdos, T., Kamath, R.V., Rugg, M.S., Day, A.J., Salustri, A., Hascall, V.C., Glant, T.T. and Mikecz, K. (2003) Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development130, 2253-2261.

2) Fülöp, C. (2005) The catalytic/structural role of tumor necrosis factor-induced protein-6 in the assembly of the cumulus extracellular matrix. In: Hyaluronan (Balazs, E.A. and Hascall, V.C., eds.), pp. 693-698, Matrix Biology Institute, New Jersey.

3) Lauer, M.E., Erzurum, S.C., Mukhopadhyay, D., Vasanji, A., Drazba, J., Wang, A., Fülöp, C. and Hascall, V.C. (2008) Differentiated murine airway epithelial cells synthesize a leukocyte-adhesive hyaluronan matrix in response to endoplasmic reticulum stress. J. Biol. Chem., 283, 26283-26296.

Research interests: Extracellular vesicles/exosomes, Endosomal transport, Cell-cell fusion, Metastasis, Drug development

1) Santos, M. F., Rappa, G., Karbanova, J., Kurth, T., Corbeil, D., and Lorico, A. VAMP-associated protein-A and oxysterol-binding protein-related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum. J Biol Chem 293, 13834-13848, 2018.

2) Rappa , Fargeas, C. A., Le, T.T., Corbeil D., and Lorico, A. An Intriguing Relationship between Lipid Droplets, Cholesterol-Binding Protein CD133 and Wnt/B-catenin Signaling Pathway in Carcinogenesis". Stem Cells 33(4):1366-70, 2015.

3) Rappa , Green T. M., and Lorico, A. The Nuclear Pool of Tetraspanin CD9  Contributes  to  Mitotic Processes in Human Breast Carcinoma. Mol Cancer Res, Dec;12(12):1840-50, 2014.

 

 

 

 

 

Research interests: G protein-coupled receptors (GPCRs), Dimerization, Receptor regulation, Receptor trafficking 

1) Prinster, S.C., N.A. Schulte, M.R. Collins, and M.L. Toews. Up-regulation of alpha-1B adrenergic receptors with defects in G protein coupling: ligand-induced protection from receptor instability. Mol. Pharmacol. 64:1126-1135.

2) Prinster, S.C., C. Hague, R.A. Hall. Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance. Pharmacol. Rev. 57:289-98.

3) Lacatos A., A. Vicentic, A., Prinster, S.C., Hall, R.A., Kuhar, M.J. CART Peptide Activates the MAPK pathway in ATt20 cells via Putative G Protein Coupled Receptors. Neurosci. Lett. 384:198-202.

Research interests: Breast cancer, melanoma, extracellular vesicles, cancer drug resistance

1) Osti D, Del Bene M, Rappa G (co-first author), Santos M, Matafora V, Richichi C, Faletti S, Beznoussenko GV, Mironov A, Bachi A, Fornasari L, Bongetta D, Gaetani P, DiMeco F,Lorico A (co-senior author), Pelicci G. Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients. Clin Cancer Res. 2018 Oct 4.

2) Rappa, G., Santos, M.F., Green, T.M., Karbanová, J., Hassler, , Bai, Y., Barsky, S.H., Corbeil, D., & Lorico, A. Nuclear Transport of Extracellular Vesicles Through Nuclear Envelope Invagination-Associated Late Endosomes. Oncotarget 8, 14443-14461, 2017.

3) Rappa G, Mercapide J, Anzanello F, Pope R, Lorico A Biochemical and Biological Characterization of Exosomes Containing Prominin-1/CD133. Mol Cancer.12: 62, 2013.

Research interests: Schizophrenia, olfactory bulb, hippocampus, basal ganglia, complex trait analysis

1) Rioux, L. and S.E. Arnold (2005) Increased expression of retinoic acid receptors alpha in granule cells of dentate gyrus in schizophrenia, Psychiatry Research, 133(1): 13-21.

2) Rioux, L., Gelber, E.I., Parand, L., Yeh, J., Winter, R. Kazi, H.A., W. Bilker and S.E. Arnold (2005) Characterization of olfactory bulb in schizophrenia. Schizophrenia Research, 77(2-3): 229-239.

3) Misra, A, Kondaveeti, P., Nissanov, J., Barbee, K., Shewokis, P., Rioux, L., Moxon, KA. (2013). Preventing Neuronal Damage and Inflammation In-Vivo During Cortical Microelectrode Implantation Through the Use of Poloxamer P-188. J. Neural Eng. 10(1): 016011.

Research interests: Extracellular vesicles/exosomes, intracellular transport, bioimaging

1) Santos MF, Rappa G, Karbanová J, Vanier C, Morimoto C, Corbeil D,Lorico A. Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins. J Cell Mol Med. 2019 Jun;23(6):4408-4421.

2) Santos, M. F., Rappa, G., Karbanova, J., Kurth, T., Corbeil, D., and Lorico, A. VAMP-associated protein-A and oxysterol-binding protein-related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum. J Biol Chem 293, 13834-13848, 2018.

3) Rappa, G., Santos, M.F., Green, T.M., Karbanová, J., Hassler, , Bai, Y., Barsky, S.H., Corbeil, D., & Lorico, A. Nuclear Transport of Extracellular Vesicles Through Nuclear Envelope Invagination-Associated Late Endosomes. Oncotarget 8, 14443-14461, 2017

Research interests: Innate Immunity; Anti-viral Immunity; Macrophages; Flaviviruses; Transplant immunology

1) Stone A.E.L. et al. RIG-I-Like-Receptors Induce Unique and Complementary Transcriptional Programs Following West Nile Virus Infection Leading to Macrophage Polarization and Protection.Nature Communications. Published on Aug 13, 2019.

2) Stone A.E.L. et al. Hepatitis C Virus Core Protein Inhibits Interferon Production by a Human Plasmacytoid Dendritic Cell Line and Dysregulates Interferon Regulatory Factor-7 and Signal Transducer and Activator of Transcription (STAT) 1 Protein Expression.PLoS One 1;9(5):e95627, 2014.

3) Stone A.E.L. et al.Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells. PLoS Pathog 9(4): e1003316, 2013.