Basic Science Faculty Research

Learn more about research being conducted by our faculty in the Department of Basic Sciences.

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Research Interests

  • Alzheimer’s disease
  • Hypoxia,
  • Medicinal plants
  • Cancer
  • Visual signal transduction

Publications

  • Stephanie Boue, Brett Fields, Julia Hoeng, Jennifer S Park, Manuel C Peitsch, Walter K Schlage, Marja Talikka, Ilona Binenbaum, Vladimir Bondarenko, et al. (2015)  Enhancement of COPD biological networks using a web-based collaboration interface F1000Research, 4:32 (doi: 10.12688/f1000research.5984.1)
  • Akio Yamazaki, Yuji Nishizawa, Isao Matsuura, Fumio Hayashi, Jiro Usukura and Vladimir Bondarenko (2013)  Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: comparison with brain tau. BBA Molecular Bases of Disease1832(10): 1549–59.
  • Daria A. Gaykalova, Nagarajavel Vivekananthan, Vladimir A. Bondarenko, Blaine Bartholomew, David J. Clark and Vasily M. Studitsky, (2011) A Polar Barrier to Transcription is Circumvented by Remodeler-induced Nucleosome Translocation. Nucleic Acids Res., 39(9):3520-8.

Research Interests

  • Anatomy
  • Morphology
  • Locomotion
  • Evolutionary biology
  • Ontogeny

Publications

  • Congdon, KA, Jason Jergenson and Kevin O’Mary (2019, in review) “Factors affecting the placement of the tibial tunnel in ACL repair: A multivariate analysis”. Current Orthopaedic Practices.
  • Congdon, KA and MJ Ravosa (2016) “Get a grip: Substrate orientation and digital grasping pressures in strepsirrhines.” Folia Primatologica, 87: 224-243.
  • Congdon, KA, AS Hammond and MJ Ravosa (2012). “Differential limb loading in miniature pigs (Sus scrofa domesticus): A test of chondral modeling theory.” Journal of Experimental Biology, 215: 1472-1483.

Research Interests

  • Extracellular vesicles/exosomes
  • Endosomal transport
  • Cell-cell fusion
  • Metastasis
  • Drug development

Publications

Learn more about Dr. Lorico's Research

Research Interests

  • Breast cancer
  • Melanoma
  • Extracellular vesicles
  • Cancer drug resistance

Publications

  • Osti D, Del Bene M, Rappa G (co-first author), Santos M, Matafora V, Richichi C, Faletti S, Beznoussenko GV, Mironov A, Bachi A, Fornasari L, Bongetta D, Gaetani P, DiMeco F,Lorico A (co-senior author), Pelicci G. Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients. Clin Cancer Res. 2018 Oct 4.
  • Rappa, G., Santos, M.F., Green, T.M., Karbanová, J., Hassler, , Bai, Y., Barsky, S.H., Corbeil, D., & Lorico, A. Nuclear Transport of Extracellular Vesicles Through Nuclear Envelope Invagination-Associated Late Endosomes. Oncotarget 8, 14443-14461, 2017.
  • Rappa G, Mercapide J, Anzanello F, Pope R, Lorico A Biochemical and Biological Characterization of Exosomes Containing Prominin-1/CD133. Mol Cancer.12: 62, 2013.

Research Interests

  • Schizophrenia
  • Olfactory bulb
  • Hippocampus
  • Basal ganglia
  • Complex trait analysis

Publications

  • Rioux, L. and S.E. Arnold (2005) Increased expression of retinoic acid receptors alpha in granule cells of dentate gyrus in schizophrenia, Psychiatry Research, 133(1): 13-21.
  • Rioux, L., Gelber, E.I., Parand, L., Yeh, J., Winter, R. Kazi, H.A., W. Bilker and S.E. Arnold (2005) Characterization of olfactory bulb in schizophrenia. Schizophrenia Research, 77(2-3): 229-239.
  • Misra, A, Kondaveeti, P., Nissanov, J., Barbee, K., Shewokis, P., Rioux, L., Moxon, KA. (2013). Preventing Neuronal Damage and Inflammation In-Vivo During Cortical Microelectrode Implantation Through the Use of Poloxamer P-188. J. Neural Eng. 10(1): 016011.

Research Interests

  • Extracellular vesicles/exosomes
  • Intracellular transport
  • Bioimaging

Publications

  • Santos, M.F., Rappa, G., Karbanová, J., Vanier, C., Morimoto, C., Corbeil, D., and Lorico, A. (2019). Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins. Journal of Cellular Molecular Medicine, 23, 4408–4421.
  • Rappa, G., Puglisi, C., Santos, M.F., Forte, S., Memeo, L., and Lorico, A. (2019). Extracellular vesicles from thyroid carcinoma: the new frontier of liquid biopsy. International Journal of Molecular Sciences, 20, 1114.
  • Osti, D., Del Bene, M., Rappa, G., Santos, M., Matafora, V., Richichi, C., Faletti, S., Beznoussenko, G., Mironov, A., Bachi, A., Fornasari, L., Bongetta, D., Gaetani, P., DiMeco, F., Lorico, A., and Pelicci, G. (2019). Clinical significance of extracellular vesicles in plasma from glioblastoma patients. Clinical Cancer Research, 25, 266–276.

Research Interests

  • Innate Immunity
  • Anti-viral Immunity
  • Macrophages
  • Flaviviruses
  • Transplant immunology

Publications

  • Stone, A.E.L., Green, R., Wilkins, C. et al. RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection. Nat Commun 10, 3649 (2019). https://doi.org/10.1038/s41467-019-11250-5
  • Burchill MA, Roby JA, Crochet N, WindRotolo M, Stone AE, Edwards MG, et al. (2017) Rapid reversal of innateimmune dysregulation in blood of patients and livers of humanized mice with HCV followingDAA therapy. PLoS ONE 12(10): e0186213.https://doi.org/10.1371/journal. pone.0186213
  • Stone, A. E., & Gale, M. J. (2017). Beyond sensing: Retinoic acid inducible gene-I (RIG-I) continues to expand its antiviral effector functions. Hepatology, 65(6), 1792-1795. doi:10.1002/hep.29161