Roadmap to the New Normal

Whether classes are online or in-person, Touro Nevada continues in its mission to provide high quality education. For information on classes and business operations, read Touro University Nevada's Roadmap to the New Normal and all Coronavirus updates. Touro Nevada students continue to provide free K-12 tutoring, undergraduate tutoring, or other community assistance. View #MedReady to learn more.

Basic Science Faculty Research

View the most recent research of our faculty in the Department of Basic Sciences.

Research interests: Alzheimer’s disease, hypoxia, medicinal plants, cancer, visual signal transduction

1) Stephanie Boue, Brett Fields, Julia Hoeng, Jennifer S Park, Manuel C Peitsch, Walter K Schlage, Marja Talikka, Ilona Binenbaum, Vladimir Bondarenko, et al. (2015)  Enhancement of COPD biological networks using a web-based collaboration interface F1000Research4:32 (doi: 10.12688/f1000research.5984.1)

2) Akio Yamazaki, Yuji Nishizawa, Isao Matsuura, Fumio Hayashi, Jiro Usukura and Vladimir Bondarenko (2013)  Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: comparison with brain tau. BBA Molecular Bases of Disease1832(10): 1549–59.

3) Daria A. Gaykalova, Nagarajavel Vivekananthan, Vladimir A. Bondarenko, Blaine Bartholomew, David J. Clark and Vasily M. Studitsky, (2011) A Polar Barrier to Transcription is Circumvented by Remodeler-induced Nucleosome Translocation. Nucleic Acids Res., 39(9):3520-8.

 

Research interests: Anatomy, morphology, locomotion, evolutionary biology, ontogeny

1) Congdon, KA, Jason Jergenson and Kevin O’Mary (2019, in review) “Factors affecting the placement of the tibial tunnel in ACL repair: A multivariate analysis”. Current Orthopaedic Practices.

2) Congdon, KA and MJ Ravosa (2016) “Get a grip: Substrate orientation and digital grasping pressures in strepsirrhines.” Folia Primatologica87: 224-243.

3) Congdon, KA, AS Hammond and MJ Ravosa (2012). “Differential limb loading in miniature pigs (Sus scrofa domesticus): A test of chondral modeling theory.” Journal of Experimental Biology215: 1472-1483.

Research interests: Extracellular vesicles/exosomes, Endosomal transport, Cell-cell fusion, Metastasis, Drug development

Extracellular Vesicles as Biological Shuttles for Targeted Therapies.

Raimondo S, Giavaresi G, Lorico A, Alessandro R.Int J Mol Sci. 2019 Apr 15;20(8):1848. doi: 10.3390/ijms20081848.PMID: 30991632 

Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins.

Santos MF, Rappa G, Karbanová J, Vanier C, Morimoto C, Corbeil D, Lorico A.J Cell Mol Med. 2019 Jun;23(6):4408-4421. doi: 10.1111/jcmm.14334. Epub 2019 Apr 13.PMID: 30982221 

Extracellular Vesicles from Thyroid Carcinoma: The New Frontier of Liquid Biopsy.

Rappa G, Puglisi C, Santos MF, Forte S, Memeo L, Lorico A

 

 

 

 

 

Research interests: Breast cancer, melanoma, extracellular vesicles, cancer drug resistance

1) Osti D, Del Bene M, Rappa G (co-first author), Santos M, Matafora V, Richichi C, Faletti S, Beznoussenko GV, Mironov A, Bachi A, Fornasari L, Bongetta D, Gaetani P, DiMeco F,Lorico A (co-senior author), Pelicci G. Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients. Clin Cancer Res. 2018 Oct 4.

2) Rappa, G., Santos, M.F., Green, T.M., Karbanová, J., Hassler, , Bai, Y., Barsky, S.H., Corbeil, D., & Lorico, A. Nuclear Transport of Extracellular Vesicles Through Nuclear Envelope Invagination-Associated Late Endosomes. Oncotarget 8, 14443-14461, 2017.

3) Rappa G, Mercapide J, Anzanello F, Pope R, Lorico A Biochemical and Biological Characterization of Exosomes Containing Prominin-1/CD133. Mol Cancer.12: 62, 2013.

Research interests: Schizophrenia, olfactory bulb, hippocampus, basal ganglia, complex trait analysis

1) Rioux, L. and S.E. Arnold (2005) Increased expression of retinoic acid receptors alpha in granule cells of dentate gyrus in schizophrenia, Psychiatry Research, 133(1): 13-21.

2) Rioux, L., Gelber, E.I., Parand, L., Yeh, J., Winter, R. Kazi, H.A., W. Bilker and S.E. Arnold (2005) Characterization of olfactory bulb in schizophrenia. Schizophrenia Research, 77(2-3): 229-239.

3) Misra, A, Kondaveeti, P., Nissanov, J., Barbee, K., Shewokis, P., Rioux, L., Moxon, KA. (2013). Preventing Neuronal Damage and Inflammation In-Vivo During Cortical Microelectrode Implantation Through the Use of Poloxamer P-188. J. Neural Eng. 10(1): 016011.

Research interests: Extracellular vesicles/exosomes, intracellular transport, bioimaging

Santos, M.F., Rappa, G., Karbanová, J., Vanier, C., Morimoto, C., Corbeil, D., and Lorico, A. (2019). Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins. Journal of Cellular Molecular Medicine, 23, 4408–4421.

Rappa, G., Puglisi, C., Santos, M.F., Forte, S., Memeo, L., and Lorico, A. (2019). Extracellular vesicles from thyroid carcinoma: the new frontier of liquid biopsy. International Journal of Molecular Sciences, 20, 1114.

Osti, D., Del Bene, M., Rappa, G., Santos, M., Matafora, V., Richichi, C., Faletti, S., Beznoussenko, G., Mironov, A., Bachi, A., Fornasari, L., Bongetta, D., Gaetani, P., DiMeco, F., Lorico, A., and Pelicci, G. (2019). Clinical significance of extracellular vesicles in plasma from glioblastoma patients. Clinical Cancer Research, 25, 266–276.

Research interests: Innate Immunity; Anti-viral Immunity; Macrophages; Flaviviruses; Transplant immunology

1) Stone, A.E.L., Green, R., Wilkins, C. et al. RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection. Nat Commun 10, 3649 (2019). https://doi.org/10.1038/s41467-019-11250-5

2) Burchill MA, Roby JA, Crochet N, WindRotolo M, Stone AE, Edwards MG, et al. (2017) Rapid reversal of innateimmune dysregulation in blood of patients and livers of humanized mice with HCV followingDAA therapy. PLoS ONE 12(10): e0186213.https://doi.org/10.1371/journal. pone.0186213

3) Stone, A. E., & Gale, M. J. (2017). Beyond sensing: Retinoic acid inducible gene-I (RIG-I) continues to expand its antiviral effector functions. Hepatology, 65(6), 1792-1795. doi:10.1002/hep.29161